Richard Moriggl contributed to a recent publication in oncotarget demonstrating that sustained activation of STAT5 induced by Bcr-Abl in chronic myeloid leukemia (CML) cells promotes production of reactive oxygen species (ROS) by repressing expression of two antioxidant enzymes, catalase and glutaredoxin-1(Glrx1). Downregulation of catalase and Glrx1 expression was also observed in primary cells from CML patients.
Researchers from the LBI and the University Vienna now made a fast and simple tool for the assessment of RNA-Seq normalization strategies avaialble. They describe their approach in a recent paper in the journal bioinformatics.
Casanova contributed to a paper by Erhard Hofer of the Medical University of Vienna entitled: Maintenance therapy with histamine plus IL-2 induces a striking expansion of two CD56bright NK cell subpopulations in patients with acute myeloid leukemia and supports their activation, which was published in Oncotarget