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New paper out on EGFR-signaling protecting from liver injury

Emilio Casanova contributed to a recent manuscript demonstrating that STAT3 protects from cholestatic liver injury. Specific ablation of STAT3 in liver cells aggravated liver damage and fibrosis in a mouse model for cholestatic disease. Upregulation of bile acid biosynthesis genes and downregulation of epidermal growth factor receptor (EGFR) expression were observed, the functional consequences of these processes in cholestatic liver injury remained unclear.

New paper out on STAT5 promoting oxidative stress in chronic myeloid leukemia

Richard Moriggl contributed to a recent publication in oncotarget demonstrating that sustained activation of STAT5 induced by Bcr-Abl in chronic myeloid leukemia (CML) cells promotes production of reactive oxygen species (ROS) by repressing expression of two antioxidant enzymes, catalase and glutaredoxin-1(Glrx1). Downregulation of catalase and Glrx1 expression was also observed in primary cells from CML patients.