Emilio Casanova contributed to a recent manuscript demonstrating that STAT3 protects from cholestatic liver injury. Specific ablation of STAT3 in liver cells aggravated liver damage and fibrosis in a mouse model for cholestatic disease. Upregulation of bile acid biosynthesis genes and downregulation of epidermal growth factor receptor (EGFR) expression were observed, the functional consequences of these processes in cholestatic liver injury remained unclear.
Richard Moriggl contributed to a recent publication in oncotarget demonstrating that sustained activation of STAT5 induced by Bcr-Abl in chronic myeloid leukemia (CML) cells promotes production of reactive oxygen species (ROS) by repressing expression of two antioxidant enzymes, catalase and glutaredoxin-1(Glrx1). Downregulation of catalase and Glrx1 expression was also observed in primary cells from CML patients.
Researchers from the LBI and the University Vienna now made a fast and simple tool for the assessment of RNA-Seq normalization strategies avaialble. They describe their approach in a recent paper in the journal bioinformatics.
Casanova contributed to a paper by Erhard Hofer of the Medical University of Vienna entitled: Maintenance therapy with histamine plus IL-2 induces a striking expansion of two CD56bright NK cell subpopulations in patients with acute myeloid leukemia and supports their activation, which was published in Oncotarget