The European Research Initiative of ALK-related malignancies (ERIA) forms the core of a successful proposal for a European Training Network (ETN). Suzanne Turner of the University of Cambridge, Lukas Kenner (LBI-CR) and Olaf Merkel (Medical University Vienna) formed a consortium around some of the leading researchers focussing in malignancies driven by the oncogene ALK to facilitate the development of less-toxic and more efficacious therapies. The consortium developed a competitive training programme for twelve PhD students, which is complemented by an array of companies.
Combined chemotherapy and immunotherapy shows promise for advanced prostate cancers. Immune cell manipulation plus chemotherapy achieves prostate cancer remission in mouse models where chemotherapy alone fails, which was reported on April 29 in the presitgious journal Nature.
A tumour suppressive role for a molecule previously believed to contribute to the progression of lung cancer has been revealed, in a mouse model, this week in Nature Communications. This new role applies specifically to mutations often found in patients with a history of smoking.
Acute leukemias develop rapidly and without treatment they lead to death within a few months. Their causes are largely unresolved. Florian Grebien of the Ludwig Boltzmann Institute for Cancer Research would like to change this, also with the help of a recently received ERC START grant.
The Charles Rodolphe Brupbacher Foundation bestowed recently their biennial prize to five young investigators, who contributed to their Scientific Symposium 2015. Jan Pencik received one of these awards for his research on "Aberrant STAT3-ARF signaling targets distinct subgroups of lethal prostate cancer".
The human gut has the largest surface area (400 m2) among all organs, whose size and shape are actively controlled and maintained. The gastrointestinal tract poses severe clinical problems upon chronic injury as in inflammatory bowel disease (ulcerative colitis and Crohn´s disease) during chemotherapy or targeted therapy. At least seven unique differentiated cell types are known to form the gut and they originate from intestinal epithelial stem cells (IESC). Homeostasis refers to the process maintaining the size of an organ through controlling the overall number of cells.
Florian Grebien of the Ludwig Boltzmann Institute for Cancer Research (LBI-CR) will receive a coveted Starting Grants of the European Research Council (ERC). It is the first ERC Grant, for a researcher at the Ludwig Boltzmann Gesellschaft. With the aid of EUR 1.5 million funding Grebien will expand its research group, which he founded in January 2014 with the support of the Institute. He explores how blood cancer develops and progresses with a specially developed technology platform.
The goal of the meeting is to promote and support scientists by offering them a stage to present their work and to give them a chance to assert themselves within the scientific setting, connect with other players of the health sciences community and to start new cooperations. Therefore every research area had its own session including a key note lecture and four oral presentations of the best submitted abstracts. The oral presentations in oncology were moderated by Prof. Richard Moriggl, who welcomed Prof. Nancy Hynes from the FMI in Basel to present her research on breast cancer.
Human allergies are an overreaction of the immune system and are studied in the Contact Hypersensitivity Assay (CHS), which serves as a faithful model of the human condition. In the immune system the Stat5 transcription factors are essential both for lymphocytes development and acute immune responses.