Please note this website is not updated anymore as the LBI-CR was integrated into its partner universities.
Current basic questions of mouse models aim towards the question which mutations cooperate in the development of different types of cancer. One concept requires state of the art cancer models to explore the combination of conventional with targeted therapies. Emilio Casanova has extensive expertise in the generation of modern murine models of neoplastic disease, including the Multi-hit mouse, which allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis. Moreover, the Casanova group has two industrial project collaborations.
Please note the research team of Emilio Casanova has been integrated into the partner university Medical University Vienna.
From left: Herwig Moll (Medical University Vienna), Emilio Casanova, Julian Mohrherr and Laura Wandruszka (from left)
About Emilio Casanova
Since 2014 he is Professor for "Transgenic Models in Cancer Research" at the Medical University Vienna.
He is an expert in the generation of genetically modified mice and as of 2017 he has more than 57 PubMed based publications with an excess of 3.500 citations and an h-index of 24 according to his google scholar profile. He serves continuously as reviewer for internationally reputed journals. In addition to the funding of the LBG and partner institutions towards the LBI-CR, he has been responsible to obtain more than 1.5 M€ of external funding towards his research.
EC was PhD student with Pedro Calvo and Miguel Chinchetru at the Department of Biochemistry and Molecular Biology, University of Leon, Spain. He did post-doctoral research at the German Cancer Research Center in Heidelberg with Günther Schütz and at the Biozentrum in Basel with Bernhardt Bettler. Since 2006 he runs his individual research group at the LBI-CR.
Please follow the link for a full CV of Emilio Casanova.