We are also studying normal and abnormal GI tract function and colorectal carcinomas. Current work in collaboration with international research groups is addressing regulation of the tight junction through cytokine signaling in epithelial cells and intestinal stem cells. In addition, the RM lab is involved in therapeutic intervention studies for chronic inflammatory processes and colorectal cancer prevention. We are preparing three manuscripts for publication. We are active in an international collaboration project on one NIH grant and several other international grant applications currently submitted.
Lower median survival in Colon cancer patients with concomitant absence of nuclear STAT1 and STAT3. Examples of patient TMAs with nuclear STAT1 and STAT3 staining, showing different levels of STAT expression. a. Immunohistochemical staining was scored by two board certified pathologists as negative (score 0), weak (score 1), moderate (score 2) or strong (score 3). b. Patients show reduced survival upon concomitant absence of nuclear STAT1 and STAT3.