Nilotinib contributes to arterial occlusive disease in CML-patients
Chronic myeloid leukemia (CML) is increasingly treated with the BCR/ABL1 inhibitor Nilotinib. Although otherwise well-tolerated, Nilotinib has been associated with progressive arterial occlusive disease (AOD). Our objective was to determine the exact frequency of AOD and examine effects of Nilotinib and Imatinib on endothelial cells to explain AOD-development. In contrast to Imatinib, Nilotinib was found to upregulate pro-atherogenic adhesion-proteins (ICAM-1, E-selectin, VCAM-1) on human endothelial cells.