New paper on Targeting STAT5B in T-Cell Neoplasia.
The somatic hot spot mutation in STAT5B was found in many T cell leukemia/lymphoma patients. The team of Moriggl generated and analyzed a transgenic mouse model with hematopoietic STAT5BN642H expression that caused aggressive T-cell leukemia/lymphomas. Herein, we discuss the scientific merit of our model and its relevance for pre-clinical studies.
Now published in Molecular & Cellular Oncology Volume 5, 2018 - Issue 3