Comprehensive Functional Studies on Translocation Products in AML
Chromosomal translocations are frequent events in leukemia. Often, this event fuses two genes, thereby creating novel proteins with oncogenic functions. In many cases, the molecular mechanism of cellular transformation of these translocation products is unknown. We have already established a number of cancer cell lines with inducible expression of affinity tagged variants of translocation products for a comprehensive analysis of their oncogenic activities.