Current Size: 100%

Research Project

Recombinant Protein Production

Recombinant protein production in eukaryotic cells is one of the main topics of biotechnology. One of the most critical steps is the development of appropriate vectors to express the protein of interest. Bacterial Artificial Chromosomes (BACs) containing the appropriate locus can be used as expression vectors in the protein production field. In collaboration with Dr. A. Bauer, we have developed a BAC-based vector system that improves the protein production by a factor of 10 when compared to a conventional vector in stable HEK293 cell lines.

The role of persistent Jak-Stat in prostate cancer progression and therapy

An important treatment strategy for prostate cancer patients is androgen depletion. After increased time (more then two years), however, most patients suffer from relapse due to development of androgen insensitivity. This is frequently caused by a mutated hormone-independent or amplified androgen receptor that occurs after 3-4 years of androgen ablation therapy.