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Review on Natural Killer Cell Regulation in Cancer

Interplay of type I interferons (IFNs) and natural killer (NK) cell activation during antitumor response. Type I IFNs either impact on maturation, homeostasis, and activation of NK cells, or indirectly influence NK cells to kill tumor cells via other immune cells or cells of the tumor microenvironment. Dendritic cells (DCs), in particular, are essential for NK cell priming via production of IL15. Another indirect effect of type I IFNs on NK cell function in cancer might result from modulation of surface mol

Type I interferons (IFNs) are known to mediate antitumor effects against several tumor types and have therefore been commonly used in clinical anticancer treatment. However, how IFN signaling exerts its beneficial effects is only partially understood. The clinically relevant activity of type I IFNs has been mainly attributed to their role in tumor immune surveillance. Different mechanisms have been postulated to explain how type I IFNs stimulate the immune system. On the one hand, they modulate innate immune cell subsets such as natural killer (NK) cells. On the other hand, type I IFNs also influence adaptive immune responses. Stoiber and co-workers review evidence for the impact of type I IFNs on immune surveillance against cancer and highlight the role of NK cells therein now in Frontiers in Immunology.