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Secret second life of cdk6 in lymphomas

CDK6 is an oncogenic kinase regulating the cell cycle. In CancerCell a research team led by Prof. Veronika Sexl from the Veterinary University Vienna and contributions from the LBI-CR demonstrated that CDK6 performs a kinase-independent transcriptional function in regulating expression of VEGF-Aandp16 INK4a.These observations link the cell cycle machinery and angiogenesis and reveal the presence of a fail-safe antiproliferative mechanism.
Read the full commentary by Tobias Otto and Piotr Sicinski as it appeared in Cancer Cell or the full publication